Triomune 40

Uses
Triomune is a combination HIV medicine containing three different antiretroviral agents - Stavudine, Lamivudine and Nevirapine. Triomune is used to treat Human Immunodeficiency Virus (HIV) infection in adults.

Triomune is prescribed to treat Human Immunodeficiency Virus (HIV) infection in adults. The combination of three different antiretroviral drugs (stavudine, lamivudine and nevirapine) slows the progression of the virus by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT).

Dosage and Administration
Triomune is packaged as a box of 30 tablets. Each tablet contains three different antiretroviral drugs:

• Stavudine 40mg
• Lamivudine 150mg
• Nevirapine 200mg

Each tablet of Triomune contains half of the recommended dosages of each individual active ingredient. Taking one tablet twice daily will provided the recommended daily dose of Stavudine, Lamivudine and Nevirapine.

Continue to take Triomune for as long as recommended by your doctor.

Side effects
Use of antiretroviral agents like those found in Triomune can occasionally lead to fatal cases of lactic acidosis. Signs yo umay be developing lactic acisosis can include nausea, vomiting and abdominal pain, difficulty breathing, loss of appetite, weight loss, or muscle weakness. Tell your doctor if you notice any of these side effects while taking Triomune.

Other side effects reported with use of the individual active ingredients include:

• Stavudine: severe peripheral neuropathy (usually dose related, and more common in patients with advanced HIV infection or people who have previously experienced peripheral neuropathy
• Lamivudine: nausea, vomiting, headaches, abdominal pain and discomfort, peripheral neuropathy, arthralgias, myalgias, skin rash, pancreatitis
• Nevirapine: development of rash and liver toxicity (these can be potentially life-threatening so should be watched closely)

Precautions
Do not take Triomune if you have ever had an allergic reaction to any of the active ingredients (stavudine / lamivudine / nevirapine).

Triomune must not be taken if you are pregnant or are breastfeeding.

Do not take Triomune if you have kidney or liver disease.

Triomune should only be taken if you have received previous treatment for HIV and specifically treatment with nevirapine.

Some medicines can interact negatively with Triomune. This may result in Triomune not working as intended, or Triomune can have a negative impact on the other medicines. Medicines that should not be taken with Triomune include:

• doxorubicin
• ribavirin
• trimethoprim
• sulfamethoxazole
• rifampin
• other antiretroviral agents (efavirenz, indinavir, lopinavir, nelfinavir, saquinavir, etc)
• ketoconazole
• oral contraceptives
• methadone