Ambisome

The information on this product's packaging is Turkish language only.

Uses
AmBisome (Liposomal Amphotericin B) is an antifungal antibiotic used to treat a variety of different fungal infections. It can treat systemic fungal infections of Aspergillus species, Candida species, and/or Cryptococcus species as well as Cryptococcal meningitis and Visceral Leishmaniasis. AmBisome works by killing the fungus that is causing the infection and preventing it spreading.

Dosage and Administration
AmBisome (Liposomal Amphotericin B) is administered through an intravenous drip after being needs to be reconstituted in a solution. The dosage will depend on the condition being treated.

Side effects
AmBisome (Liposomal Amphotericin B) has a wide range of possible side effects you may notice when taking it. Contact your doctor if you have any questions about these.

The following side effects have been reported by more than 10% of users in studies:

• Hypokalemia (31-51%)
• Hypomagnesemia (15-50%)
• Chills (29-48%)
• Anemia (27-48%)
• Nephrotoxicity (14-47%)
• Nausea (16-40%)
• Vomiting (11-32%)
• Diarrhea (11-30%)
• Rash (5-25%)
• Dyspnea (18-23%)
• Hyperglycemia (8-23%)
• Insomnia (17-22%)
• Alkaline phosphatase increase (7-22%)
• Infusion reaction (4-21%)
• Headache (9-20%)
• Hypertension (8-20%)
• Abdominal pain (7-20%)
• Tachycardia (9-19%)
• Lung disorder (14-18%)
• Blood transfusion reaction (9-18%)
• Hypocalcemia (5-18%)
• Cough (2-18%)
• Bilirubinemia (<18%)
• Leukopenia (15-17%)
• ALT increased (15%)
• Constipation (15%)
• Peripheral edema (15%)
• Pain (14%)
• Anorexia (10-14%)
• Anxiety (7-14%)
• Hypotension (7-14%)
• Sepsis (7-14%)
• AST increased (13%)
• Pleural effusion (13%)
• Confusion (9-13%)
• Thrombocytopenia (6-13%)
• Weakness (6-13%)
• Back pain (12%)
• Edema (10-12%)
• Hyponatremia (9-12%)
• Chest pain (8-12%)
• Hypervolemia (8-12%)
• Pruritus (11%)
• Rhinitis (11%)
• Phlebitis (9-11%)

These side effects were reported, but by less than 10% of people:

• Abnormal thinking
• Acidosis
• Agitation
• Alopecia
• Arthralgia
• Asthma
• Bruising
• Cardiovascular abnormalities
• Coagulation disorder
• Cellulitis
• Depression
• Dizziness
• Electrolyte abnormalities
• Fluid overload
• Gastrointestinal hemorrhage
• Hallucinations
• Hyperventilation
• Injection site reaction
• Malaise
• Mucositis
• Petechia
• Rash
• Renal function abnormalities
• Respiratory acidosis
• Respiratory failure
• Seizure
• Stomatitis

Precautions
AmBisome (Liposomal Amphotericin B) may not be a suitable treatment for everybody. Before you begin treatment, tell your doctor of any medicines you are taking and any allergies you have. Don't take AmBisome if you are using any azole antifungals such as ketoconazole, itraconazole or fluconazole.

Check with your doctor if you think you may be pregnant or if you are breastfeeding. AmBisome may not be suitable if you have had kidney problems.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use AmBisome (Liposomal Amphotericin B) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.