Uses
Celkeran 5 (Chlorambucil) is an aromatic derivative from the group of nitrogen-containing yperite that has an antitumor, cytostatic, immunosuppressive, alkylating effect. It is used to treat such pathologies as Hodgkin`s lymphoma, non-Hodgkin`s lymphomas (lymphosarcoma and reticulosarcoma), chronic lymphocytic leukemia, myeloma, Waldenstrom`s macroglobulinemia, Letterera-Sywa disease, ovarian cancer, breast cancer, uterine chorioepithelioma, nephrotic syndrome. Celkeran 5 (Chlorambucil) binds to nucleoproteins of cell nuclei. It affects DNA chains by alkylation through the formation of highly active ethyleneimonium radicals, causes cross-linking or breaking of DNA strands and disrupts their replication. To a lesser extent, alters the synthesis of RNA. Celkeran 5 (Chlorambucil) has a toxic effect on both dividing and non-dividing cells. It inhibits the tumor and hematopoietic tissue. It acts more selectively on lymphoid tissue than on granulocyte elements.

Dosage and Administration
Always follow your doctor`s instructions when using Celkeran 5 (Chlorambucil) to get the safest and most effective results from treatment. Celkeran 5 (Chlorambucil) should be used only on the appointment of a specialist oncologist who has experience in the treatment of such drugs and in the presence of conditions for continuous monitoring of clinical biochemical and hematological parameters during and after administration. The dosage is prescribed by the doctor individually for each patient. Typically, the dosage is 0.1-0.2 mg / kg per day, and depending on many factors, such as type of pathology, functioning of the liver, patient`s age and other.

Side effects
The use of Celkeran 5 (Chlorambucil) may cause side effects in some patients including:

• aphthous stomatitis, nausea, vomiting, diarrhea, abnormal liver function (necrosis, cirrhosis), jaundice.
• mielodepressiya (leukopenia, thrombocytopenia, anemia, lymphopenia, acute leukemia, bleeding and hemorrhage)
• cough, pneumosclerosis, interstitial pneumonia
• painful, difficult urination, hematuria, hyperuricemia, aseptic cystitis, edema,
• amenorrhea, azoospermia.
• impairment of consciousness, ataxia, peripheral neuropathy, hallucinations, partial and / or systemic epileptic seizures (neurotoxic effect).
• Stevens-Johnson syndrome, rash, dermatitis and other skin allergic reactions.
• the development of infections, fever, secondary malignancy

Precautions
Estimation of the risk-benefit ratio is necessary when prescribing in the following cases: chicken pox, systemic infections, bone marrow function suppression, bone marrow infiltration with tumor cells, prior cytotoxic or radiotherapy, gout, urolithiasis, hyperuricemia, abnormal liver and kidney function, head injury, convulsive disorders (including history), children and old age.