Trioday

Uses
Trioday is an HIV medication, combining three different active ingredients. It contains: 300mg of Tenofovir Disoproxil Fumarate, 300mg of Lamivudine, and 600mg of Efavirenz.

Tenofovir is classified as a nucleotide reverse transcriptase inhibitor (NRTI). Tenofovir disoproxil fumarate converts into tenofovir, an acyclic nucleotide analog of adenosine monophosphate. Subsequently, tenofovir turns into the active metabolite, tenofovir diphosphate Tenofovir diphosphate inhibits HIV-1 reverse transcriptase and hepatitis B virus polymerase, thereby terminating the DNA synthesis.

Lamivudine is classified as a nucleoside reverse transcriptase inhibitor (NRTI), an anti-retrovirus medication, used as part of the combined anti-retrovirus therapy to control HIV or treat hepatitis B. Lamivudine also inhibits RNA- and DNA-dependant HIV reverse transcriptase.

Efavirenz is classified as a selective HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a non-competitive HIV-1 reverse transcriptase inhibitpr, however it doesn't inhibit HIV-2 reverse transcriptase and human cells DNA polymerase (α, β, γ, and δ).

Dosage and Administration
Trioday is taken orally with a glass of water, one tablet each day at the same time, before going to bed and on an empty stomach.

It is essential that you fully comply with all directions given by your physician. Do not take more than the correct daily dosage, as this could put you at risk of serious health problems.

Side effects
Patients undergoing antiretroviral treatment with Trioday may experience side effects, especially in the beginning of treatment. The most common side effects include:

• Asthenia
• Coughing
• Depression
• Diarrhea
• Dizziness
• Fatigue
• General weakness
• Headache
• Insomnia
• Nasal symptoms
• Nausea
• Pains
• Skin rash

Precautions
Trioday may be unsafe for certain patients. The list of medical counter-indications includes:

• Concurrent treatment with terfenadine, astemizole, cisapride, midazolam, and triazolam
• Decreased kidney function
• Hypersensitivity to any components of the drug
• Intolerance to any components of the drug
• Life threatening allergic reactions to any components of the drug (such as anaphylaxis and Stevens-Johnson syndrome)
• Peripheral neuropathy
• Use in pediatric patients below 18

Before taking Trioday, consult your physician if you've experienced the following conditions in your past medical history:

• Lactate acidosis
• Hepatomegaly with steatosis
• Hepatitis exacerbation
• Kidney failure
• Liver failure
• Pancreatitis

The medication has to be used with care in patients with the apparent decrease in liver function. It is recommended to test the activity of the liver transaminases on a regular basis in patients with hepatitis B or C, or when these infections are suspected in the past medical history, as well as in patients, receiving other medications that may have hepatotoxic action. In case there is an acute persistent rise in the activity of the transaminases up to the level more than five times exceeding the upper limit of normal, it is required to assess the benefits of further treatment against the risks of significant hepatotoxic action.