Vexazone

Uses
Vexazone 30mg Tablets are used to help treat type 2 diabetes (non-insulin dependent diabetes mellitus or adult-onset diabetes) in adults. Each tablet contains 30mg of the active ingredient Pioglitazone Hydrochloride. Pioglitazone reduces the quantity of glucose in the blood by modulating the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver.

Dosage and Administration
Vexazone 30mg is the middle of three different dosages available. It it also available in a 15mg and 45mg dosage.

Your doctor will perform blood tests to determine the severity of your diabetes and prescribe a recommended dosage based on this.

Each dosage should be taken once a day, preferably at the same time each day. Swallow each tablet whole with a glass of water.

Vexazone can help control diabetes, but it works best when used with dietary and exercise programs.

Side effects
Most medicines can lead to some unwanted side effects, and Vexazone is no different. Most of the side effects you may experience will be mild and temporary. There are some side effects that will require medical attention and may result in you having to stop treatment with Vexazone.

Common side effects:

• hypoglycaemia (low blood sugar) - usually when Vexazone is taken with a sulfonylurea or insulin
• shortness of breath when resting or after minimal physical activity
• swelling of the legs, feet and hands
• increased weight
• localised swelling of the ankles, feet and hands (oedema) and/or fluid in the lungs (pulmonary oedema) which may indicate heart failure - usually when taking Vexazone with insulin
• increased risk of fracture in women
• macular oedema
• altered or impaired liver function.

Less common, and more serious side effects:

• dark urine or pale stools
• yellowing of the skin or eyes
• severe cramps of the stomach
• nausea or vomiting
• loss of weight
• tiredness
• blood in the urine
• pain and burning sensation when urinating

Precautions
Vexazone must not be taken by anybody who is allergic to pioglitazone hydrochloride, or any of the following which are also found in the tablets:

• lactose
• hypromellose
• colloidal anhydrous silica
• croscarmellose sodium
• polysorbate 80
• magnesium stearate

Prior to beginning treatment with Vexazone 30mg, notify your doctor:

• if you have any current medical conditions, as well as your past medical history
• if you are taking any medicines (this includes prescription drugs, non-prescription drugs, herbal remedies or nutritional supplements)
• if you are pregnant, trying to become pregnant, or are breast-feeding

Some medicines react poorly with pioglitazone. You may not be able to take this medicine if you are currently taking any of the following:

• chlorpropamide
• glibenclamide
• gliclazide
• insulin
• metformin
• oral contraceptives
• gemfibrozil
• rifampicin
• tolbutamide

Vexazone can make you feel tired and drowsy because of the decrease in blood glucose levels. When driving or operating machinery, make sure to be aware of this.