Acitrom

Uses
Acitrom (Nicoumalone) is an anticoagulant medicine indicated for the prevention and treatment of blood clots, such as those occurring as a result of DVT (deep vein thrombosis). It works by preventing the formation of blood clots inside the blood vessels. The active ingredient in this medicine was formerly known as acenocoumarol. Although it will not dissolve clots after their formation, it can prevent the enlargement of the blood clot, thereby helping to protect against the potential serious problems which could occur as a result of blood clots.

This medicine acts as an antagonist of vitamin K. As this vitamin is needed for the production of the proteins needed to cause a blood clot (clotting factors), preventing vitamin K activity blocks their production. Without clotting factors, the likelihood of a blood clot is significantly reduced. Other conditions for which this medicine may be used include blood clots in patients affected by rheumatic heart disease, atrial fibrillation and pulmonary embolism.

Dosage and Administration
Acitrom (Nicoumalone) comes in the form of 4mg tablets which are taken by mouth. It is usually administered as a single daily dose, however the precise amount needed will require careful calculation by your doctor. A special blood test designed to measure the time taken for blood to clot will be taken regularly. This is referred to as the INR (international normalised ratio) and it will allow your doctor to adjust your dosage. Generally, adult patients are told to take a dosage ranging from 1mg to 8mg per day, however a 4mg dosage is normally administered on day 1 of treatment. Do not take more than your doctor directs you to take.

Side effects
Acitrom (Nicoumalone) can cause the occurrence of side effects, such as:

• Nosebleeds
• Stiff joints
• Spinning sensation
• Slower blood clotting
• Bleeding occurring from the gums

You must make your doctor aware of any side effects that occur while you are being treated with this medicine. Immediate medical care will be required if you notice any serious and less common side effects, include fever, hair loss, a reduced appetite, vasculitis, bloody urine and any other reactions not listed here.

Precautions
Intramuscular injections are not possible while this medicine is being taken.

This medicine can put you at a higher than normal risk of bleeding, and you will need to be especially careful if partaking in any sporting or other high risk activities.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use Acitrom (Nicoumalone) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.

This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:

• If you are pregnant or breastfeeding.
• If you suffer from any allergies.
• If you suffer from any other health conditions or illnesses.
• If you are using any other medicine (including all non-prescription).
• If you are using any supplements, vitamins, or herbal products of any kind.