Coversyl

Uses
Coversyl (Perindopril Erbumine) treats stable coronary artery disease and hypertension by lowering the fluid in the blood vessels and allowing them to widen. This medicine is a pro-drug, and is metabolized into its active metabolite perindoprilat through a process known as hydrolysis. Its antihypertensive benefits are due to it inhibiting the activity of the angiotensin converting enzyme (commonly abbreviated to ACE).

This enzyme is known to contribute to vasoconstriction and narrowing of the blood vessels, a key cause of high blood pressure. Blocking ACE activity prevents constriction of the blood vessels and allows them to become wider. Other effects include a reduction in the secretion of aldosterone, a hormone which is produced in the adrenal gland and can affect blood pressure. This helps reduce water retention (diuresis) and helps to further contribute to the drop in blood pressure.

Dosage and Administration
Coversyl (Perindopril Erbumine) comes in tablet form and each one contains 2mg of the active ingredient. Adults undergoing treatment for coronary artery disease may be instructed by their doctor to take 4mg per day at the start of treatment for a period of two weeks, and it is possible that the doctor may titrate this dosage and direct the patient to administer 8mg once per day.

Patients taking this medicine for diabetic nephropathy, hypertension or congestive heart failure may be instructed to administer 4mg by mouth once per day as an initial dosage, and maintenance treatment may require a dosage which ranges from 4mg to 8mg per day, taken as a single dose or 2 separate doses. The dosage regimen can vary based on individual circumstances, and patients must always comply with the instructions given by their doctor.

Side effects
Treatment of your medical condition with Coversyl (Perindopril Erbumine) could lead to side effects, and a list of examples is given here:

• Flatulence
• Poor appetite
• Joint inflammation
• Aches which affect the muscles
• Tender feeling at the cheekbones

Your doctor must be made aware of any side effects that occur during treatment. Mild reactions are more common, however there is a risk of serious side effects associated with all medicines, and this one is no exception. If you notice any rare, but serious side effects, seek medical attention straight away. Examples include congestion in the ear, fever, chills, urine which is bloody or discoloured, severe fatigue and other reactions which have not been listed here.

Precautions
Regular medical checkups will be scheduled by your doctor. This is so that your blood pressure, potassium levels and the functioning of your kidneys can be checked. Attend all scheduled appointments.

This medicine is not suitable for patients suffering from kidney problems which are serious in nature.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use Coversyl (Perindopril Erbumine) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.

This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:

• If you are pregnant or breastfeeding.
• If you suffer from any allergies.
• If you suffer from any other health conditions or illnesses.
• If you are using any other medicine (including all non-prescription).
• If you are using any supplements, vitamins, or herbal products of any kind.