Veenat 100

Uses
Veenat 100 (Imatinib) is indicated for different types of cancers, in particular Philadelphia chromosome positive (Ph+) myelogenous leukaemia. It acts by affecting the growth of cancerous cells. Other applications include gastrointestinal stromal tumours (GIST, a rare type of cancer which affects the stomach and digestive system) and a skin cancer called DFSP (dermatofibrosarcoma protuberans) when it cannot be removed surgically.

Treatment of patients with Ph+ CML by means of this medicine can help to manage the symptoms and improve the MMR (major molecular response), meaning that the levels of BCR-ABL tyrosine kinase protein (the abnormal protein present in patients with Ph+ CML) is reduced. This drug is known as a tyrosine kinase inhibitor, and it helps to block the development of cancer cells. It specifically attacks the cancer cells (which have the tyrosine kinase protein) but not the non-cancerous healthy ones. This is often referred to as targeted therapy.

GISTs are believed to arise from cells in the gastrointestinal tract called ICCs (interstitial cells of Cajal). These cells play an important role in motility. An abnormal mutated protein called KIT is responsible for the tumours in most cases. By preventing phosphorylation of the KIT protein, it can help to treat GIST. Other indications include HES or CEL in certain circumstances, some myeloproliferative or myelodysplastic disorders with PDGFR gene rearrangements, and other types of cancers not listed here.

Dosage and Administration
Veenat 100 (Imatinib) is provided in capsule form. Each one contains 100mg of the active ingredient. Your doctor will provide you with specific instructions which are unique to you, based on the severity of symptoms, disease progression and the condition being treated (such as GIST, CML or dermatofibrosarcoma protuberans). Tests on platelet levels will most likely be ordered by your doctor, and the results of these tests will be used to determine the required dosage adjustments. Adults are usually directed to take it once or twice per day, together with food and water.

Side effects
Administration of Veenat 100 (Imatinib) as part of a medical treatment schedule could cause some side effects, for example:

• Tiredness
• Dizziness
• Constipation
• Stiff muscles
• Sleep problems

The occurrence of any side effects, no matter how mild, must be promptly reported to the doctor responsible for medical treatment. Seek immediate treatment if you suffer from skin blistering, discoloured urine, passing urine more frequently than normal, unusual reflexes, pain in the back or any other side effects which are serious in nature and have not been listed here.

Precautions
Cases of oedema and fluid retention have been reported in some patients who took this medicine. Left ventricular dysfunction and serious congestive heart failure have also occurred. These conditions will all require immediate medical attention. Discuss the risks of treatment with your doctor before taking this medicine.

This medication is not to be administered to pregnant women.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use Veenat 100 (Imatinib) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.

This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:

• If you are pregnant or breastfeeding.
• If you suffer from any allergies.
• If you suffer from any other health conditions or illnesses.
• If you are using any other medicine (including all non-prescription).
• If you are using any supplements, vitamins, or herbal products of any kind.