Sandomigran

Uses
Sandomigran (Pizotifen Malate) is used for the prophylaxis (prevention) of migraine headaches and attacks. It works by acting on the blood vessels and serotonin receptors in the brain. The active ingredient in this drug is known as a serotonin antagonist and after administration, it inhibits the 5HT (serotonin) receptors which are found inside the brain. This in turn blocks the dilation of the blood vessels (which is believed to play a part in causing migraines).

Serotonin can also cause other chemicals to be released which can contribute to this widening of the blood vessels in the brain. It also has anticholinergic and antihistamine benefits. Medical studies have shown that treatment with this medicine can decrease the frequency at which headaches occur. Headaches that do occur may also be less severe in nature. Other types of vascular headaches have also been treated with this medicine, such as vasomotor headaches and cluster headaches.

Dosage and Administration
Sandomigran (Pizotifen Malate) is administered orally. The medicine content of each tablet is 0.5mg. Your doctor will conduct a medical assessment to determine whether or not this medicine is a suitable treatment for your condition. Some patients will be directed to take one tablet per day. If your doctor deems it necessary, your dosage may be increased to 3 tablets per day. Further adjustments may be needed if the headaches are not sufficiently controlled. However, you must not make any adjustments to your dosage unless your doctor tells you to do so.

Side effects
Patients undergoing treatment with Sandomigran (Pizotifen Malate) may experience side effects, such as:

• Tiredness
• Sleepiness
• Weight gain
• Appetite increases
• Dryness that affects the mouth

It is necessary to inform your doctor of any side effects which occur during treatment. There is a possibility that other reactions which have not been listed here may occur. If any severe reactions occur, you must immediately consult your doctor.

Precautions
These tablets are not used to treat a migraine attack that has already begun. It is not effective for this purpose and is only used to prevent headaches.

If you abruptly stop treatment, there is a possibility that withdrawal symptoms may occur. In order to stop this, your doctor may make special adjustments to your dosage regimen, including gradual reduction of the dosage.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use Sandomigran (Pizotifen Malate) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.

This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:

• If you are pregnant or breastfeeding.
• If you suffer from any allergies.
• If you suffer from any other health conditions or illnesses.
• If you are using any other medicine (including all non-prescription).
• If you are using any supplements, vitamins, or herbal products of any kind.