Sinemet

Uses
Sinemet (Carbidopa/Levodopa) is used to treat patients for Parkinson's disease, a condition which can cause movement difficulties, tremors and rigidity. Depleted levels of a neurotransmitter known as dopamine (which is important in helping the body and nerves to function normally) in the corpus striatum is believed to be responsible for the occurrence of the negative effects that Parkinson's disease has on skeletal muscle control and mobility.

After this medication is taken, the body quickly decarboxylates the levodopa (one of the active ingredients) to dopamine. This can result in improved movement and relief from other symptoms. The other ingredient in this medicine (carbidopa) helps to ensure that a higher amount of levodopa reaches the brain, and can also lessen nausea and vomiting (side effects of levodopa), and make it easier for the doctor to determine the correct dosage.

Dosage and Administration
Sinemet (Carbidopa/Levodopa) is a combination medicine. Each tablet contains 25mg of carbidopa and 100mg of levodopa (at a ratio of 1:4). The doctor will need to closely monitor the patient during treatment, so as to observe any possible signs of a worsening of symptoms. The dosage may then be carefully adjusted, so as to find a suitable amount. If any other medicines for the treatment of Parkinson's disease have been prescribed, the doctor will need to take this into account when deciding the correct dosage. It is essential to fully obey any dosage instructions given by your doctor.

Side effects
There is a possibility that patients taking Sinemet (Carbidopa/Levodopa) may notice some side effects, such as:

• Insomnia
• Itchy skin
• Sore muscles
• Symptoms of a cold
• A decrease in appetite

Patients who experience side effects should inform their doctor. It is also important to be aware of the risk of severe reactions. Any patient who experiences seizures, tremors which are worse than before, painful urination or any other serious side effects which have not been listed here will need immediate medical treatment.

Precautions
During treatment with this medicine, it is possible that you may experience gambling urges or other unusual urges. If this occurs, see your doctor.

In some cases, patients undergoing treatment for Parkinson's disease have been affected by melanoma (skin cancer). It may be necessary for your doctor to schedule regular checks on your skin.

Seek immediate emergency medical attention if you suffer an allergic reaction. Symptoms to watch for, which may be indicative of a reaction, include skin rashes, hives, swelling of the face or limbs, trouble breathing, and trouble swallowing.

Always use Sinemet (Carbidopa/Levodopa) as you have been prescribed by your doctor. Never self-medicate or change your dosage without first consulting your doctor. The correct dosage can vary depending on your health, medical history, and the severity of the condition being treated.

This medication may not be safe for all patients. Before you begin using it always disclose the following to your doctor:

• If you are pregnant or breastfeeding.
• If you suffer from any allergies.
• If you suffer from any other health conditions or illnesses.
• If you are using any other medicine (including all non-prescription).
• If you are using any supplements, vitamins, or herbal products of any kind.